Bioassay of 2-nitro-p-phenylenediamine for possible carcinogenicity. by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.

Cover of: Bioassay of 2-nitro-p-phenylenediamine for possible carcinogenicity. | National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.

Published by Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Cancer Institute, Division of Cancer Cause and Prevention, Carcinogenesis Testing Program in Bethesda, Md .

Written in English

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Subjects:

  • Carcinogens.,
  • Dyes and dyeing -- Toxicology.,
  • Phenylenediamine -- Toxicology.

Edition Notes

Book details

SeriesCarcinogenesis technical report series ; no. 169, DHEW publication ; no. (NIH) 79-1725, DHEW publication -- no. (NIH) 79-1725.
The Physical Object
Pagination98 p. in various pagings :
Number of Pages98
ID Numbers
Open LibraryOL18014051M

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A bioassay for the possible carcinogenicity of 2-nitro-p-phenylenediamine was conducted using Fischer rats and B6C3F1 mice. 2-Nitro-p-phenylenediamine was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each ://   A bioassay for the possible carcinogenicity of 2—nitro-p-phe­ nylenediamine was conducted using Fische 34r4 rats and B6C3F1 mice.

2-Nitro-p-phenylenediamine was administere idn the feed, at Get this from a library. Bioassay of 2-nitro-p-phenylenediamine for possible carcinogenicity. [National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.]   BIOASSAY OF 4-NITRO-o-PHENYLENEDIAMINE FOR POSSIBLE CARCINOGENICITY.

CAS No. NCI-CG-TR U.S. DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE. Public Health Service National Institutes of Health   2-Nitro-p-phenylenediamine: Target Organs and Levels of Evidence for TR Bioassay of 2-Nitro-p-phenylenediamine for Possible Carcinogenicity (CASRN ) Chemical (Study Title) Groups of 50 male and 50 female B6C3F1 mice were given 2-nitro-p-phenylenediamine Bioassay of 2-nitro-p-phenylenediamine for possible carcinogenicity.

book the feed at either or ppm for 78 wk. Twenty animals of each sex were used as ent was followed by a 12–13 wk observation period. There was a dose-related depression of   A bioassay for the possible carcinogenicity of 2-nitro-p-phenylenediamine was conducted using Fischer rats and B6C3F1 mice.

2-Nitro-p-phenylenediamine was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. Twenty animals of each sex and species were placed on test as :// A bioassay for the possible carcinogenicity of 4-nitro-o-phenylenediamine was conducted using Fischer rats and B6C3F1 mice.

4-Nitro-o-phenylenediamine was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. Twenty animals of each sex and species were placed on test as ://   EPA has not classified p-phenylenediamine with respect to carcinogenicity.

Physical Properties The chemical formula for p-phenylenediamine is C6H8N2, and its molecular weight is g/mol. (2) p-Phenylenediamine occurs as a white to slightly red solid or crystals that darken on exposure to air; it is slightly soluble in water.

(2,4,7)   TR Bioassay of 2-Nitro-p-phenylenediamine for Possible Carcinogenicity (CAS No. ) "2-Nitro-p-phenylenediamine. a component of both semipermanent and permanent hair dye formulations, was Bioassay of 2-nitro-p-phenylenediamine for possible carcinogenicity. book for bioassay by the National Cancer Institute because of the increased incidence of bladder cancer among dye manufacturing industry a bioassay for possible carcinogenicity of 2-chloro-p-phenylenediamine sulfate was conducted using rats and mice.

the compound was administered in the feed, at either of 2 concentrations, to groups of male and female animals of each :// Myhr, B.C., and Caspary, W.J.

Evaluation of the LY mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics,  › Home › Chemical Effects in Biological Systems (CEBS).

Bioassay of n-phenyl-p-phenylenediamine for possible carcinogenicity (OCoLC) Material Type: Government publication, National government publication: Document Type: Book: All Authors / Contributors: National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.

OCLC Number: Notes: "CAS no. " Description: Bioassay of 2-chloro-p-phenylenediamine sulfate for possible carcinogenicity (CAS No. National Toxicology Program. Natl Cancer Inst Carcinog Tech Rep Ser,01 Jan Cited by: 0 articles | PMID: Applicant's summary and conclusion Conclusions: Sub-chronic toxicity tests were conducted with both rats and mice.

Rats were distributed among six groups, each consisting of five males and five females. 2-Nitro-p-phenylenediamine was incorporated into the basal laboratory diet and supplied ad libitum to five of the six rat groups in concentrations of,and mg/:// Carcinogenesis Technical Report Series No.

Bioassay of 2-Nitro-p-phenylenediamine for Possible Carcinogenicity. CAS No. NCI-CG-TR US Department of Health and Human Services, National Institutes of Health. Wenninger, J. FDA's research and regulatory programs for cosmetics and :// A bioassay of N-phenyl-p-phenylenediamine for possible carcinogenicity was conducted by administering the test chemical in the diet to Fischer rats and B6C3F1 mice.

Groups of 50 rats of each sex were administered /the test cmpd/ at one of two doses, either or 1, ppm, for 78 wk and were then observed for an additional 26 wk.

Matched 1. Author(s): Litton-Bionetics, inc.; National Institutes of Health (U.S.); Carcinogenesis Testing Program (U.S.) Title(s): Bioassay of 2-nitro-p-phenylenediamine for ().

Bioassay of 2-chloro-p-phenylenediamine sulfate for possiblecarcinogenicity. Bioassay of 2-nitro-p-phenylenediamine for possible carcinogenicity. Bioassay of 2,4-dinitrotoluene for possible carcinogenicity.

Bioassay of 2,6-dichloro-p-phenylenediamine for possible carcinogenicity. Get this from a library. Bioassay of 4-chloro-o-phenylenediamine for possible carcinogenicity. [National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.] A bioassay of 5-nitro-o-anisidine for possible carcinogenicity was conducted using Fischer rats and B6C3F1 mice.

/The cmpd/ was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each ://   Long-Term Carcinogenicity. 2-Year (Dosed-Feed) (C) Completed. TR (NIH Number: ) (Peer Review Approval 08/31/A) Bioassay of 2-Nitro-p-phenylenediamine for Possible Carcinogenicity (CASRN ) Rats: F/N; Mice: B6C3F1; Carcinogenesis Results.

Male Rats Negative ; Female Rats Negative ; Male Mice Negative 2-Nitro-p-phenylenediamine (Cas No. Dietary administration of 2 -nitro- p -phenylenediamine was reported to be carcinogenic to female B6C3F 1 mice, causing an increased incidence of   National Cancer Institute.

Bioassay of 2-nitro-p-phenylenediamine for possible carcinogenicity. CAS No. ITS Carcinogenesis Technical Report Ser ies No. DHEW Publication No. (NIH} U. Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of ://   2-Chloro-p-Phenylenediamine and 2-Chloro-p-Phenylenediamine Sulfate are colorants used in hair dyes at concentrations less than %.

In an oral subchronic toxicity test using rats and mice, all male rats and one female rat died in the 1 % concentration of 2-Chloro-p-Phenylenediamine dose group; at %, no rats or mice died but the mean body weight gain was ://   Dominant lethal studies in rats of five hair dye components: 2-nitro-p-phenylenediamine, 4-nitro-o-phenylenediamine, m-phenylenediamine, 2,4-diaminoanisole sulfate, and 2,5-diaminoanisole sulfate.

Toxicol. Appl. Pharmacol. 45, Google Scholar National Cancer Institute (b) Bioassay of 2-nitro-p-phenylenediamine for possible carcinogenicity. Bethesda, MD. Public Health Service, National Institutes of Health, National Cancer Institute.

(Carcinogenesis, Technical Report Series No ) [DHEW Publication No   PubMed:Bioassay of 2-nitro-p-phenylenediamine for possible carcinogenicity.

PubMed: The mutagenic assay of some hair dye components, using the thymidine kinase locus of LY mouse lymphoma cells. PubMed: Testing of known carcinogens and noncarcinogens for their ability to induce unscheduled DNA synthesis in HeLa 1.

Author(s): Litton-Bionetics, inc.; National Institutes of Health (U.S.); Carcinogenesis Testing Program (U.S.) Title(s): Bioassay of 4-nitro-o-phenylenediamine for   Study population.

The Copenhagen City Heart Study is a prospective study of the general population of Copenhagen, Denmark, initiated in – with follow-up examinations in –, –, –, and – [12,13].Participants aged 20 years and older were randomly selected from the general population using the Danish civil registration system [].

Mutation Research, () Elsevier MTR Mutagenicity of selected aniline derivatives to Salmonella following plant activation and mammalian hepatic activation James M. Gentile 1, Glenda J. Gentile 1 and Michael J. Plewa 2 * Biology Department, Hope College, Holland,and 2 Institute for Environmental Studies, University of Illinois, Urbana, IL (U.S.A Differences in gene expression profiles in the liver between carcinogenic and non-carcinogenic isomers of compounds given to rats in a day repeat-dose toxicity study A bioassay for possible carcinogenicity of 2-NpP was conducted using Fischer rats and Anonymous, b.

Bioassay of 2-nitro-p-phenylenediamine for possible   2-chloronitro-N-hydroxyethyl p-phenylenediamine has low acute oral toxicity in female CF1 mice. There are no data on acute dermal and inhalation toxicity.

Irritation. Only limited data are available in guinea pigs. 2-chloronitro-N-hydroxyethyl p-phenylenediamine at a % concentration is not irritating to the :// Monocyclic aromatic amino and nitro compounds [MAK Value Documentation, ] toxicity, genotoxicity and carcinogenicity, classification in a carcinogen category National Cancer Institute (b) Bioassay of 2-vitro-p-phenylenediamine for possible carcinogenicity, Careinogenesis Technical report No.

), DHEW Publ. NCI-TR, Washington DC. Perry, P., and H.J. Evans () Cytological detection of mutagen-carcinogen exposure by sister-chromatid exchange, Nature (London), The hair dye constituents p-phenylenediamine, 2,4-diaminoanisole sulfate, 2,4-diaminotoluene and 4-nitrophenylenediamine were tested for mutagenicity in Drosophila melanogaster.

The compounds /_Use_of_hair_dyes_and_risk_of_blood_cancer. Its carcinogenicity has been studied only with high doses but these produced high levels of induced tumours.

Although the available data is limited, the analogy to the structurally similar substances 4,4'-diaminodiphenylmethane and 4,4'-oxydianiline justifies the classification of 4,4'-thiodianiline in Section III A 2) of the MAK    J. Chem. Inf. Comput. Sci.39, Predictive Carcinogenicity: A Model for Aromatic Compounds, with Nitrogen-Containing Substituents, Based on Molecular Descriptors Using an Artificial Neural Network Giuseppina Gini* and Marco  › 百度文库 › 行业资料.

In order to evaluate the in vivo genotoxic potential of three putative genotoxic mouse liver carcinogens, high doses of 4-chloro-o-phenylenediamine, 2-nitro-p-phenylenediamine and 2, 4 Groups of 50 male and 50 female B6C3F1 mice were given 2-nitro-p-phenylenediamine in the feed at either or ppm for 78 wk.

Twenty animals of each sex were used as controls. Treatment was. Abstract. The utility of information acquired from the application of genetic tests to the safety evaluation of agricultural chemicals such as animal drugs or pesticides, involves the same considerations that are used for other environmental ://In order to evaluate the in vivo genotoxic potential of three putative genotoxic mouse liver carcinogens, high doses of 4-chloro-o-phenylenediamine, 2-nitro-p-phenylenediamine and 2, 4-diaminotoluene were tested short term in the Big Blue{reg_sign} transgenic mouse mutation ://  Recent carcinogenicity studies conducted and evaluated by the National Toxicology Program/National Institute of Environmental Health Sciences were examined to determine the frequency of chemically increased incidences of neoplasia.

Many of the chemicals originally selected for study were chosen because of an a priori suggestion that they might be carcinogens. Of the chemical studies

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